It's hard for me to imagine San Diego as anything but run-down; part of the city's appeal right now is that everything is really fresh, bright, and uncongested (this should change over the next few years).

However, there are reminders that not-so-long-ago, downtown San Diego was run-down. I posted a picture from my boss' place yesterday; in this picture, there is a tall skyscraper which I've outlined for highlighting purposes:

Today's game of the day: Given this building's primo real estate location, guess what this building is. Here is a google maps link here